New paper in collaboration with Prof. Peter Grace from MD Anderson, showing that TSPO is upregulated in the rat brain after peripheral nerve injury is downregulated by the drug diroximel fumarate is out!

We are pleased to announce a new publication in collaboration with Prof. Peter Grace from MD Anderson titled ‘18 kDa Translocator protein (TSPO) is upregulated in rat brain after peripheral nerve injury and downregulated by diroximel fumarate’.

Neuroimmune signaling is a key process underlying neuropathic pain. Clinical studies have demonstrated that 18 kDa translocator protein (TSPO), a putative marker of neuroinflammation, is upregulated in discrete brain regions of patients with chronic pain. However, no preclinical studies have investigated TSPO dynamics in the brain in the context of neuropathic pain and in response to analgesic treatments. We used positron emission tomography-computed tomography (PET-CT) and [¹⁸F]-PBR06 radioligand to measure TSPO levels in the brain across time after chronic constriction injury (CCI) of the sciatic nerve in both male and female rats.

Please read the full article here.