We are pleased to announce a new publication in collaboration with Prof. Mainero titled “Phenotyping In Vivo Chronic Inflammation in Multiple Sclerosis by Combined 11C-PBR28 MR-PET and 7T Susceptibility-Weighted Imaging.”
Background: 11C-PBR28 positron emission tomography (PET), targeting the translocator protein, and paramagnetic rim lesions (PRL) have emerged as promising imaging markers of MS chronic inflammation. No consensus on which is the optimal marker exists.
To investigate the ability of 11C-PBR28 PET and PRL assessment to identify chronic inflammation in white matter (WM) MS lesions and their relation to neurological impairment, researchers find that 11C-PBR28 imaging reveals more active WM lesions than 7T PRL assessment. Although PRL and PET active lesion counts are related, neurological disability is better explained by PET whole active lesion volume.
Please read the full article here.