Background: The study of inflammation in chronic pain conditions has evolved dramatically over the past decade, largely thanks to the pioneering work of researchers like Marco Loggia, Associate Professor of Radiology and Anesthesia at Harvard Medical School. Loggia’s research, employing cutting-edge imaging techniques such as PET and fMRI, has provided invaluable insights into neuroinflammation’s role in chronic pain and its potential as a therapeutic target. His investigations began with an exploration of Translocator Protein (TSPO), a marker of inflammation, to map neuroimmune activity in human chronic pain conditions. This work unveiled distinct neuroinflammatory profiles in conditions like chronic low back pain, fibromyalgia, and Gulf War Illness. Furthermore, these studies emphasized how neuroinflammation correlates with not only the physical experience of pain but also its emotional and cognitive dimensions. Loggia’s research trajectory highlights the importance of collaboration and innovation in advancing pain science. His work bridges the gap between animal models and human studies, offering a comprehensive view of inflammation’s multifaceted role in chronic pain.

We extend our gratitude to Marco for his decade-long contributions to the field of chronic pain research and Dr. Emily Mills for writing the journey.

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